![]() ![]() These multi-platform metabolomics analyses were in accord with the results of behavior study, histopathological observations, and biochemical analyses. The regulated metabolites affected by AR were involved in the pathway of arginine biosynthesis, arginine and proline metabolism, ether lipid metabolism, glutathione metabolism, primary bile acid biosynthesis, and steroid biosynthesis. With the pre-treatment of AR, 32 metabolites in the serum of AD model rats were significantly affected by AR compared with the AD model group. A total of 49 biomarkers associated with the AD model were identified by metabolomics, and pathway analysis was performed to obtain the metabolic pathways closely related to the model. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-QTOF/MS) were combined with multivariate statistical analysis to identify potential biomarkers of AD and evaluate the therapeutic effect of AR on AD from the perspective of metabolomics. Behavior study, histopathological observations, and biochemical analyses were applied in the AD model assessment. This study aims to evaluate AR’s therapeutic effect and mechanism on AD model rats induced by D-galactose and AlCl 3 with serum metabolomics. However, the effect and its molecular mechanism are not elucidated clear. Скачать / download: CW Skimmer 2.Anemarrhenae Rhizoma (AR) has multiple pharmacological activities to prevent and treat Alzheimer’s disease (AD). ![]() + a DSP processor with a noise blanker, AGC, and a sharp, variable-bandwidth CW filter + the extracted callsigns are exported as DX cluster spots via the built-in Telnet cluster server + the callsigns are extracted from the decoded messages, and the traces on the waterfall are labeled with stations' callsigns + a fast waterfall display, with a resolution sufficient for reading Morse Code dots and dashes visually ![]() + simultaneous decoding of ALL cw signals in the receiver passband - up to 700 signals can be decoded in parallel on a 3-GHz P4 if a wideband receiver is used + a high sensitivity CW decoding algorithm based on the methods of Bayesian statistics A fast waterfall display, with a resolution sufficient for reading Morse Code dots and dashes visually. Up to 700 signals can be decoded in parallel on a 3-GHz P4 if a wideband receiver is used. Simultaneous decoding of "ALL" cw signals in the receiver passband. A very sensitive CW decoding algorithm based on the methods of Bayesian statistics. ![]()
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